Polynucleotide treatments are designed to work with your body’s natural repair processes and are not typically reversible. However, since the treatments are non-invasive and use natural DNA fragments, any effects will gradually diminish over time if maintenance treatments are not continued.
Polynucleotides
Benefits of Polynucleotide Treatments
As we age, our skin loses its ability to regenerate and repair, leading to the appearance of fine lines, wrinkles, and other signs of ageing. Polynucleotide treatments at Dr Sknn Aesthetic Skin Clinic in the UK address these issues by introducing purified DNA fragments that stimulate the skin's natural repair processes, resulting in healthier, more youthful-looking skin. These treatments are also effective in combating issues related to hair loss and skin texture.
How Do Polynucleotides Work?
Polynucleotides work by stimulating cell proliferation and regeneration. When applied to the skin using techniques such as microneedling, nanoneedling, microboluses with a fine needle, or using a cannula, they activate receptors on skin cells, leading to:
Increased production of collagen and elastin
Improved hydration through enhanced hyaluronic acid production
Strengthening of micro-blood vessels, promoting better blood flow and nutrient delivery
Regulation of melanocyte function, reducing pigmentation and evening out skin tone
Reduction in inflammation, helping to calm and soothe the skin
Microneedling or nanoneedling enhances the penetration of polynucleotides, making the treatment more effective by allowing the active ingredients to reach deeper layers of the skin. These mechanisms help to restore the skin's natural glow, reduce the signs of ageing, and improve overall skin health.


Areas Treated with Polynucleotide Therapy
Polynucleotide treatments are highly versatile and can be applied to various areas of the face and body. These treatments are tailored to address specific concerns such as fine lines, wrinkles, scarring, pigmentation, and hair loss, making them an excellent option for comprehensive skin and hair rejuvenation.
Face Treatment with Polynucleotides
The face is one of the most common areas treated with polynucleotide therapy. As we age, the skin on our face loses elasticity and volume, leading to the appearance of fine lines, wrinkles, and sagging. Polynucleotide treatments can help to:
- Reduce Fine Lines and Wrinkles: By stimulating collagen and elastin production, polynucleotides smooth out wrinkles and fine lines, particularly around the eyes (crow's feet), mouth (laugh lines), and forehead.
- Improve Skin Texture and Hydration: Polynucleotides enhance skin hydration, leading to a smoother and more youthful complexion. They also help to even out skin tone, reducing the appearance of pigmentation and sun damage.
- Revitalise Tired-Looking Skin: The treatment promotes the regeneration of skin cells, giving the face a more vibrant and refreshed appearance.
Under Eyes and Eyelids Treatment with Polynucleotides
The delicate skin under the eyes and on the eyelids is particularly susceptible to aging, leading to dark circles, puffiness, and sagging. Polynucleotide treatments can specifically target these areas to:
- Reduce Dark Circles: By improving microcirculation and stimulating collagen production, polynucleotides can help to lighten dark circles under the eyes.
- Tighten Sagging Skin: The treatment helps to firm the delicate skin under the eyes and on the eyelids, reducing the appearance of bags and sagging.
- Smooth Fine Lines: Polynucleotides can also smooth out fine lines and wrinkles around the eyes, giving a more youthful and refreshed appearance.
Neck Treatment with Polynucleotides
The décolletage, or the upper chest area, is another area where polynucleotide treatments can be highly effective. This delicate area is prone to sun damage and aging, resulting in wrinkles, sunspots, and a loss of skin elasticity. Polynucleotide therapy can:
- Rejuvenate the Décolletage: By stimulating cell regeneration, polynucleotides can smooth out wrinkles and fine lines, improving the overall texture and appearance of the skin.
- Reduce Pigmentation and Sun Damage: The treatment helps to even out skin tone and reduce the appearance of sunspots, giving the décolletage a more youthful look.
- Enhance Skin Firmness: Polynucleotides help to restore elasticity to the skin, making it firmer and more resilient.
Décolletage Treatment with Polynucleotides
The décolletage, or the upper chest area, is another area where polynucleotide treatments can be highly effective. This delicate area is prone to sun damage and aging, resulting in wrinkles, sunspots, and a loss of skin elasticity. Polynucleotide therapy can:
- Rejuvenate the Décolletage: By stimulating cell regeneration, polynucleotides can smooth out wrinkles and fine lines, improving the overall texture and appearance of the skin.
- Reduce Pigmentation and Sun Damage: The treatment helps to even out skin tone and reduce the appearance of sunspots, giving the décolletage a more youthful look.
- Enhance Skin Firmness: Polynucleotides help to restore elasticity to the skin, making it firmer and more resilient.
Abdominal Treatment with Polynucleotides
The abdomen is another area that can benefit from polynucleotide treatments, especially for individuals who have experienced significant weight loss, pregnancy, or stretch marks. The treatment can:
- Firm and Smooth the Skin: Polynucleotide therapy helps to tighten and smooth the skin on the abdomen, reducing the appearance of loose or saggy skin.
- Reduce Stretch Marks: By stimulating collagen production and cell regeneration, polynucleotides can help to fade stretch marks, making them less visible and improving the skin's overall texture.
- Improve Skin Texture: The treatment enhances the overall texture and firmness of the abdominal skin, leading to a more toned and youthful appearance.
Thigh/Leg Treatment with Polynucleotides
The thighs are a common area of concern, particularly when it comes to cellulite, skin laxity, and stretch marks. Polynucleotide treatments can:
- Reduce Cellulite: The treatment can help to reduce the appearance of cellulite by improving the skin’s firmness and elasticity.
- Fade Stretch Marks: Polynucleotide therapy can help to reduce the appearance of stretch marks on the thighs by stimulating collagen production, which promotes the regeneration of healthy skin cells.
- Enhance Skin Firmness: Polynucleotides stimulate collagen and elastin production, which can improve the texture and firmness of the skin on the thighs, giving them a smoother and more toned appearance.
Buttocks Treatment with Polynucleotides
For those seeking a smoother, more toned appearance in the buttocks, polynucleotide treatments offer several benefits:
- Enhance Skin Elasticity: Polynucleotides can help to improve the elasticity of the skin on the buttocks, making it firmer and more resilient.
- Reduce Dimpling and Stretch Marks: The treatment can reduce the appearance of dimpling and stretch marks on the buttocks, leading to a smoother, more even skin surface.
- Improve Overall Texture: Polynucleotide therapy enhances the overall texture of the skin, making it smoother and more toned.
Arm Treatment with Polynucleotides
The skin on the arms, particularly the upper arms, can become loose and saggy with age or after significant weight loss. Polynucleotide treatments can:
- Tighten and Firm the Skin: By stimulating collagen production, the treatment helps to tighten loose, sagging skin on the upper arms, often referred to as "bat wings."
- Smooth Wrinkles and Improve Texture: Polynucleotides can also improve the overall texture of the skin on the arms, making it smoother and more youthful-looking.
Hand Treatment with Polynucleotides
The hands are often one of the first places to show signs of aging due to constant exposure to the elements. Polynucleotide treatments can:
- Rejuvenate Aging Hands: By increasing collagen and elastin production, polynucleotides help to reduce the appearance of wrinkles and fine lines on the hands.
- Improve Skin Tone and Hydration: The treatment also enhances skin hydration and reduces pigmentation, giving hands a more youthful and even-toned appearance.
Scalp and Hair Treatment with Polynucleotides
Polynucleotide treatments can also be applied to the scalp to address hair loss and promote healthier hair growth. The treatment works by:
- Stimulating Hair Follicles: Polynucleotides encourage the regeneration of hair follicles, leading to thicker, healthier hair.
- Improving Scalp Health: The treatment can enhance the overall health of the scalp, reducing issues such as dryness or irritation.
Eyelash Growth Treatment with Polynucleotides
Polynucleotide treatments offer a cutting-edge solution for individuals seeking to enhance their natural eyelashes, providing a non-invasive method to strengthen, lengthen, and volumize lashes. The treatment can:
Strengthen and Thicken Lashes: Polynucleotide therapy helps to fortify the lashes, making them stronger and reducing breakage. This results in fuller, more resilient eyelashes.
Stimulate Natural Growth: By stimulating the hair follicles, polynucleotides promote the natural growth of longer, thicker lashes, enhancing their overall appearance.
Improve Lash Health: The treatment nourishes the lash line, improving the overall health and vitality of your lashes, making them look and feel healthier and more vibrant.
What to Expect Before the Procedure
At Dr Sknn Aesthetic Skin Clinic, we offer a free, doctor-led consultation before any polynucleotide treatment. During this consultation, a full medical history will be taken, and a detailed assessment of your skin's condition will be conducted. The clinician will explain the procedure, potential risks, and expected outcomes. Each treatment plan is customised to address your specific skin concerns and achieve the best possible results.
What to Expect During the Procedure
What to Expect After the Procedure
Before & Afters
Frequently Asked Questions
Can Polynucleotide Treatments Be Reversed?
Are Polynucleotide Treatments Safe?
Yes, polynucleotide treatments are considered safe when administered by a trained and qualified professional. The polynucleotides used are highly purified and closely resemble human DNA, reducing the risk of adverse reactions. The treatment has been supported by scientific research and is widely used in both aesthetic and regenerative medicine.
Are Polynucleotide Treatments Painful?
Polynucleotide treatments are generally well-tolerated by patients. A topical numbing cream can be applied before the procedure to minimize any discomfort. Some patients may experience mild sensations during the injection process, but these are typically brief and manageable.
What Type of Polynucleotide is Used in the Treatment?
Do Polynucleotide Treatments Have Any Side Effects?
How Long Do Polynucleotide Treatment Results Last?
The results of polynucleotide treatments can vary depending on the individual and the area treated. Generally, patients can expect the effects to last for several months, with gradual improvement seen over time. For long-lasting results, maintenance treatments every 6 to 12 months are recommended.
Who is Unsuitable for Polynucleotide Treatments?
Polynucleotide treatments may not be suitable for individuals with certain medical conditions, allergies, or skin infections in the treatment area. A thorough consultation with a qualified clinician at Dr Sknn Aesthetic Skin Clinic will help determine if this treatment is right for you.
Am I Suitable for Polynucleotide Treatments?
What Should I Avoid After Polynucleotide Treatments?
Where Can Polynucleotide Treatments Be Used?
Can Polynucleotide Treatments Be Combined With Other Procedures?
Yes, polynucleotide treatments can be combined with other aesthetic procedures, such as anti-wrinkle injections or dermal fillers, to enhance overall results. Your clinician will discuss the best combination of treatments to achieve your desired outcome.
What Results Will I See With Polynucleotide Treatments?
Patients typically notice improvements in skin texture, hydration, and elasticity within a few weeks of treatment. Over time, you may also see a reduction in fine lines, wrinkles, skin quality and pigmentation. When used for hair loss, new hair growth and improved hair quality may also be observed. Results will vary based on individual factors, including skin condition and lifestyle.